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[13] [15] There is a risk of oxalate nephropathy or kidney stone formation, particularly in patients with pre-existing renal impairment or those receiving prolonged high-dose therapy

Crosstalk between different cell death pathways may also be related to resistance to targeted therapy, and the induction of different types of cell death, such as ferroptosis, through targeted therapy has become a new strategy in kidney cancer treatment (139)

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