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If you were to inject your previous maintenance dose, say 1.0 mg or 2.4 mg, into a body with zero tolerance, the result would be extreme

Spinler is professor and chair of the department of pharmacy services in the School of Pharmacy and Pharmaceutical Sciences at Binghamton University

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The iron sulfur centers (Fe-S) within the respiratory complexes are in turn inhibited, diminishing their resistance to calcium (Ca 2+ )-dependent mitochondrial permeability transition