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Mediating role of bone marrow lesions, synovitis, pain sensitization, and depressive symptoms on knee pain improvement following substantial weight loss

L.W., W.H., A.R., N.K., Y.Y., D.Y

Several of the proteins identified in STEP 1 and STEP 2 are known to be related to obesity and T2D pathophysiology and their associated complications, including C-reactive protein (CRP), adipokines (leptin, adiponectin), ghrelin, insulin-like growth factor binding protein (IGFBP), growth hormone receptor (GHR), neural cell adhesion molecule 1 (NCAM1) and netrin receptor (UNC5D), among others

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Appetite Regulation: GLP-1 receptor agonists help control hunger by targeting the brains appetite centers