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LL-37 is discussed in autoimmune skin disease because it can drive immune activation in certain settings

Chang CH et al

Introduction Vitamin B12 (cobalamin) deficiency is prevalent in the elderly, with estimates indicating that approximately 20% of individuals aged 60 and over, and 23-35% of those aged 80 and above, are affected

This enzyme catalyzes the N-methylation of nicotinamide using S-adenosyl-L-methionine (SAM) as a methyl donor, effectively creating a "metabolic drain" that depletes both NAD+ precursors and cellular methylation capacity

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