Clinical trials consistently demonstrate reductions in total cholesterol, LDL cholesterol, and triglycerides, largely mediated through weight loss
Data availability The study was approved by the Mass General Brigham Institutional Review Board
They typically lessen over time as your body adapts: Eat smaller, more frequent meals rather than large meals Avoid lying down immediately after eating Stay away from very fatty, greasy, or spicy foods initially Eat slowly and stop when you feel satisfied, not stuffed Stay well-hydrated throughout the day Take your injection on a day when you can rest if you experience side effects When to Contact Your Provider Contact your healthcare provider if you experience: Severe abdominal pain that doesnt resolve Persistent vomiting that prevents adequate hydration Signs of pancreatitis (severe upper abdominal pain radiating to your back) Symptoms of gallbladder problems (pain in the upper right abdomen, yellowing of skin or eyes) Significant changes in vision Signs of kidney problems (changes in urination, swelling) Most people tolerate semaglutide well, and side effects, while common, are typically manageable and temporary
This pattern indicates that even clinically non-severe exposures can generate considerable healthcare utilization, the authors wrote
They are not approved for weight loss or obesity management
