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Inflammation, infection, tissue injury, pregnancy and estrogen exposure may raise it

Spatial transcriptomics combined with single-cell RNA sequencing identified high expression levels of ferroptosis-related genes, including TFRC, NCO4, and SLC3A2, in granulosa cells of patients with ovarian senescence, while GPX4 expression was notably low ( BNC1 mutations that lead to premature follicular activation and atresia (Zhang et al., 2018)

Collectively, these molecular modifications engender a self-reinforcing cycle of mitochondrial dysfunction, oxidative damage, and inflammation that expedites the deterioration of both muscular and vascular systems

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Notably, Indomethacin, a widely used non-steroidal anti-inflammatory drug, stands out for its potent AKR1C3 inhibitory properties