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The primary endpoint was the time to first occurrence of MACE, which included CV death, nonfatal myocardial infarction, or nonfatal stroke

Current studies suggest that peripherally administered GLP-1RA has low concentrations in the cerebrospinal fluid, and higher doses or improved delivery systems (e.g., nanoparticles, liposome encapsulation) may be needed to increase brain exposure

OSR administration significantly reduced chondrocyte apoptosis (TUNELpositive cells), collectively indicating functional repair of OA-damaged cartilage

10.1016/0014-5793(94)01326-v FEBS Lett

Two studies analyzing the first few weeks of warfarin treatment showed the proportion of patients with INR values of more than 3 to be higher among carriers of the CYP2C9*2 or *3 allele than in patients that were not carriers of these alleles (43,44)