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Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2

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For instance, the average Indian diet provides around 2 to 2.5 grams of turmeric per day for a 60 kg individual (around 132 lbs), which only translates to around 60 to 100 mg of curcumin

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Although melasma is a non-malignant skin disorder, however, if a proper, well-timed, and optimum therapeutic regimen is not considered, it can induce various psychological and emotional distress including feelings of frustration, unattractiveness, and embarrassment (Wu et al., 2021)