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Consistent with the kinetic of ligand-induced GLP-1R internalization (Fig

Initial week 1 loss is usually minimal (0-2 pounds) despite appetite suppression because steady-state medication levels haven't fully developed

In the case that one has at least one medical condition resulting from obesity, like hypertension, diabetes, sleep apnea, etc., this drug could be used starting at a BMI of 27, which would be equivalent to a lower weight compared to healthier individuals

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