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For patients who do not have chronic kidney disease or cardiovascular disease but have at least three risk factors from Table 1 , SGLT-2 inhibitors decrease mortality with an NNT of 100 (95% CI, 67 to 167) over five years

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Induction was more pronounced in cynomologus than in patas monkeys, with no apparent sex difference and with a pattern of results that is consistent with that previously seen in rodents

10.3389/fimmu.2017.00055 87 LiH.ChenW.ChenY.ZhouQ.XiaoP.TangR.et al (2019a)