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However, progesterone resistance exists in ectopic and endometrial stromal cells of women with EMS, and in the secretory phase, progesterone resistance in ectopic endometrium stromal cells may alter the effect induced by UPR as described above (88, 89)

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There were two further phase IIa studies evaluating cotadutide with the first one showing that it reduced glucose levels in those with obesity and T2DM with the mechanism being greater insulin secretion and delayed gastric emptying [46]

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