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Several xenobiotics induce PPAR activity, resulting in liver enlargement by stimulating the proliferation of hepatocyte peroxisomes and inducing the fatty acid oxidation enzyme CYP4A in rats and mice (Bentley et al

And it can be helped by clinician-supported weight loss treatments, like GLP-1s

Proksch E, Schunck M, Zague V, et al

In a landmark phase 2a substudy focusing on patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), the highest doses of retatrutide triggered a staggering relative reduction in liver fat (Sanyal et al., 2024)

Brennan Harris, College of William and Mary, United States Nikos Margaritelis, Aristotle University of Thessaloniki, Greece Matthew J