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developmental code PNB-0408) is a synthetic small oligopeptide derived from angiotensin IV (AngIV), engineered to overcome AngIVs limitations as a research tool by adding lipophilic modifications that confer oral bioavailability and blood-brain barrier permeability

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ROS drive HIF-1-BNIP3/NIX-mediated mitophagy and alleviate cell apoptosis and inflammation in M9a+sh EPAS1 cells during hypoxia To identify the cause of induced mitophagy, we explored the role of ROS, given their involvement in stabilizing HIF-1 [22, 28]