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In addition to increasing total body fat and visceral fat, these hormonal changes in estradiol and testosterone levels also cause changes to muscle mass including: reduced muscle regeneration, increased programmed cell muscle death

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2-Amino-5-(carbamoylamino)pentanoic acid

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10.1038/ejcn.2016.119 143

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Khoja L, Day D, and Wei-Wu Chen T, et al (2017) Tumour- and class-specific patterns of immune-related adverse events of immune checkpoint inhibitors: a systematic review Annals of Oncology 28 (10) 23772385 PMID: 28945858 44

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