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First-in-human study of safety, pharmacodynamics of lb54640, an oral melanocortin-4 receptor agonist

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10.3389/fendo.2022.1033479 38 ElsonJ

In 2025, a study known as the STEP UP trial was conducted into the efficacy of the new Wegovy 7.2mg dose, and saw that over 72 weeks there was an average weight loss of 21%, compared to just 2.4% of people on a placebo

The alimentary limb was anastomosed to the gastric pouch, and the biliopancreatic limb was anastomosed 15 cm distally to gastrojejunal anastomosis