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This metabolite specifically targets and stabilizes PD-L1, which suppresses the activity of tumor-infiltrating T lymphocytes and leads to increased recruitment and activity of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) and tumor-associated macrophages (TAMs) ( In microsatellite stable (MSS) colorectal cancer, tumor cells exhibit asynchronous disruption of the cholesterol biosynthesis pathway, leading to the accumulation of distal cholesterol precursors such as desmosterol and zymosterol
Funding HCJ discloses support for the research of this work from the Prime Ministers Research Fellowship, Ministry of Education, Government of India [PMRF ID: 2100556], the Department of Science and Technology, Government of India, under the Fund for Improvement of S&T Infrastructure scheme [SR/FST/LS-I/2020/621], and Anusandhan National Research Foundation (ANRF) for funding through the PAIR scheme (File No: ANRF/PAIR/2025/000018/PAIR-A(G))
