Ross D, Siegel D
Figure 2 5.1.2 Tumor suppression by bilirubin effects on proto-oncogene/oncogene signaling pathways 5.1.2.1 B-cell lymphoma-2 The Bcl-2 protein family supervises the integrity of the cellular genome to inhibit tumor growth ( p38 and p53 downstream, ultimately leading to the increased regulation of the pro-apoptotic protein Bax and the decreased regulation of the anti-apoptotic protein Bcl-2 and phosphorylation of Bcl-xL/Bcl-2 associated death promoter (Bad) ( Bilirubin, an endogenous antioxidant, has a dramatic antitumor impact on the carcinoma of colon and rectum cell lines
3729-C EMPOWERING THE FRONTLINE: ENHANCING HEPATITIS C TREATMENT ACCESSIBILITY IN PRIMARY CARE THROUGH PROCESS DESIGN AND RESIDENT EDUCATION Rita Auro, Michael Schwartz and Alexandra Lane, Cooper University Health Care Background: In 2022, the World Health Organization (WHO) recommended simplifying the hepatitis C virus (HCV) care pathway to improve treatment access, advocating for diagnosis and management in primary care (PC) settings
However, controversy exists regarding if one treatment is better than the other
Our data emphasize the co-occurring nature of PSC symptoms, identify highly influential symptoms, and highlight the need to develop patient-reported outcome measures to assess changes in these key symptoms in clinical trials
