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Preserving normal pulsatile release of GH is critical to ensuring that proper release of downstream hormones, such as insulin-life growth factor-2 (IGF-1)

As demonstrated in 1 H-NMR of CDs reduced by NaBH 4 (CDs-NaBH 4 ), a significant increase of the peaks in the region of 1.02.0 ppm was observed, indicating that the C=O of CDs was reduced to C-O, respectively (Figure 5D)

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Consequently, any potential application in adolescents remains speculative and requires confirmation through dedicated pediatric clinical trials