Incretin-based GLP-1 therapies have additional effects, e.g., the reduction of glucagon, the slow down of gastric emptying, and inducing the sense of satiety
Besides, zinc is also involved in the inhibition of invasion and adhesion in malignant prostate cancer cell through several ways: strongly prevents the enzymatic activity of prostate-specific antigen (PSA) and suppresses the invasion of LNCaP cells, 360 reduces the expression of vascular endothelial growth factor (VEGF), 361 interleukin (IL)-6, IL-8, matrix metalloproteinase-9 (MMP9), intercellular adhesion molecule-1 (ICAM1), diminished the activity of urokinase-type plasminogen activator and aminopeptidase N (AP-N) 362 (Fig

Author Contributions Conceptualization: LI, KEW, NWS Methodology: LI, KEW, NWS Formal Analysis: LI, ST, CD, TM, NK, AF Investigation: LI, ST, CD, JD, TM, NK, AF, PN, LR, JS, HA, AC Visualization: LI Supervision: KEW, NWS, BC, AA Writing - original draft: LI, KEW Writing - review & editing: LI, KEW, NWS, ST, AC, BC, AA, CD, JD, TM, NK, AF, PN, LR, JS, HA Competing Interests No competing interests declared Data and Material Availability All data needed to evaluate the conclusions in the paper are present in the paper and/or the Supplementary Materials
Ca-AKG supports one part of metabolism
9 Mechanisms of anti-depressant action of flavonoids Preclinical studies suggest antidepressant properties in naturally occurring flavonoids, though the mechanisms remain unclear