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We have no idea how long that immunosuppression lasts

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Step-by-step cold compress protocol: Timing: Apply within 1 hour of noticing the reaction for best results Preparation: Wrap ice pack or frozen gel pack in a thin cloth or paper towel, never place ice directly on skin Application: Press gently against the affected area for 10 to 15 minutes Frequency: Repeat every 2 to 3 hours during the first 24 hours Duration: Continue cold compress therapy for the first 48 hours Safety: Never exceed 15 minutes per application, check skin for signs of frostbite (white, waxy appearance) A pre-injection cold application also helps

Liu C, Li Y, Hu S, Chen Y, Gao L, Liu D, Guo H, Yang Y (2018) Clinical significance of matrix metalloproteinase-2 in endometrial cancer: a systematic review and meta-analysis

2011;93:S52S59