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Constipation is a listed side effect of semaglutide, but left untreated can lead to far more serious outcomes like ileus, which have the potential to be fatal

J Endocrinol Metab 11(5):95107 Liu Y et al (2023) The weight-loss effect of GLP-1RAs glucagon-like peptide-1 receptor agonists in non-diabetic individuals with overweight or obesity: a systematic review with meta-analysis and trial sequential analysis of randomized controlled trials

It is vital to consider the safety profiles of these medications, as Tirzepatide has been linked to a higher incidence of gastrointestinal side effects compared to Semaglutide