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Key areas of investigation include modulation of the nitric oxide (NO) system through interaction with NOS isoforms, upregulation of growth factor receptors (including VEGFR2 and EGF receptor systems), and engagement of the FAK-paxillin signaling cascade associated with cell migration and adhesion

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A total of 12 metabolites were identified, including 8 phase I metabolites (predominantly -ketone reduction, N-dealkylation, and hydroxylation products) and 4 phase II glucuronide conjugates

Kennedy Jr., who oversees the FDA and other major health agencies as the secretary of Health and Human Services, knows this history