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Glyburide In a single-dose interaction study in type 2 diabetes patients, co-administration of metformin and glyburide did not result in any changes in either metformin pharmacokinetics or pharmacodynamics

Additionally, some participants on the highest dose achieved weight reductions of 25% or even 30%, which is comparable to the outcomes typically seen with bariatric surgery

It has an immense amount of longitudinal data re obesity & claims cost

University of Iowa Hospitals & Clinics

JAMA 309:22502261 Chang SH, Stoll CR, Song J, Varela JE, Eagon CJ, Colditz GA (2014) The effectiveness and risks of bariatric surgery: an updated systematic review and meta-analysis, 2003-2012