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The use of statins at higher concentrations than in the present study has been previously associated with varying effects on insulin secretion: simvastatin was shown to reduce, while pravastatin increased insulin secretion in response to glucose, with GLP-1 or exendin-4 exposure restoring secretory responses from statin-treated cells (48)

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El-Mir, M

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Oral brownish pigmentation has also been reported in human immunodeficiency virus (HIV)-positive patients receiving treatment with zidovudine (AZT), ketoconazole and clofazamine (29)