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Effects of NK1 receptors on gastric motor functions and satiation in healthy humans: results from a controlled trial with the NK1 antagonist aprepitant

Patients with prior gallbladder issues (common in obesity) face compounded risks, as GLP-1s promote rapid weight loss and gallstone formation (2-5% incidence)

A systematic review has showed that a 5%10% weight reduction improves cardiometabolic parameters, including BP, blood glucose level and dyslipidemia (32)

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Potential considerations include: Gastrointestinal sensitivity during therapy initiation