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Such an association requires the NADP presence, strongly tied by the enzyme 7,8 which makes that NADP performs a dual role not only as structural component but as a coenzyme 9-11

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GPX4 converts GSH to oxidized glutathione while reducing toxic lipid peroxides (L-OOH) to their corresponding alcohols (L-OH), thus lowering ROS production (Yang and Stockwell, 2016