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This is a classic example of taking Y to increase X. Rather than flooding the body with carnitine and hoping for the best, increasing choline availability helps the body retain and utilize carnitine more effectively
doi: 10.1016/j.bbrc.2019.01.090 91 LowensteinPRCastroMG
As this review summarises evidence from wider community- and hospital-based HFpEF populations, it provides useful context for mortality outcomes outside the RCT setting
Individual results vary significantly based on adherence, diet, exercise, and starting weight
David Kellner, MD: It's area where there's not a lot of definitive data, but it is known that when you lose weight with a GLP-1 medication, some of that weight is going to be muscle mass
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