One trial examining semaglutide in individuals with AUD demonstrated lower alcohol intake, but reported inconsistent effects on heavy drinking days
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Highlights from study findings include: 751 individuals participated in the study The mean percent change in weight at week 72 was -20.2% for those taking tirzepatide and -13.7% for those taking semaglutide The most common side effects were gastrointestinal A 2025 real-world study of over 2,300 patients treated at an academic obesity clinic also showed meaningful weight loss, especially among those who stayed on therapy for at least a year
By week 12, cumulative weight loss of 56% of baseline body weight is common in clinical trials, though individual results vary
These results underscore the high degree of clinical effectiveness of semaglutide in adolescents with obesity, the report concluded
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