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Furthermore, it also induces the expression of mitochondrial transcription factor A (TFAM), a controller in replication and transcription of mitochondrial DNA, to further drive mitochondrial biogenesis (Jornayvaz and Shulman, 2010

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However, dangerous levels of methemoglobinemia only occur in patients with glucose-6-phosphate dehydrogenase (G6PDH) deficiency and, thus, this drug should not be administered to anyone with a deficiency in this enzyme

Although there is a general consensus that endothelial dysfunction is a reliable indicator of the advancement of atherosclerosis and potential cardiovascular events, additional research is needed to fully understand its impact on hypertension and platelet hyperactivity

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