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Calorie restriction appears to affect neurobiological pathways that control appetite, hunger, cravings and body weight, such that there is increased food intake and weight gain (Brown et al, 2022)

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However, GLP-1 RA therapy has gastrointestinal side effects, including nausea, increases the risk of undernutrition, and can decrease lean body mass

A meta-analysis comparing clinical effects of short- or long-acting GLP-1 receptor agonists versus insulin treatment from head-to-head studies in type 2 diabetic patients