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Consequently, the compromised BBB allows the virus to breach the brain's protected environment while also permitting the entry of pro-inflammatory cytokines

Fraser A, Harris R, Sattar N, Ebrahim S, Smith GD, Lawlor DA

Laboratory studies of the patient's blood revealed a CEA level of 45.57 ng per millilitre (reference range, 0.05.0), a CA19-9 level of 30.53 U per millilitre (reference range, 0.027.0) and a haemoglobin level of 90 g per litre (reference range, 110150 g per litre)

However, it is associated with dose limiting gastrointestinal side effects and should be avoided in any patient at risk of lactic acidosis (serum creatinine 1.4 ng/dL for females and 1.5 ng/dL for male, or heart failure exacerbation), patients receiving contrast dyes, or those with significant hepatic dysfunction

The follow-up periods in these trials typically ranged from 1.5 to 5 years, providing medium-term safety data