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The decline of NAD + with age results from three converging factors: (1) increased activity of CD38, a NADase whose expression increases with age-related chronic inflammation (inflammaging), (2) reduced biosynthesis via the NAMPT (nicotinamide phosphoribosyltransferase) and NMN pathways, and (3) increased demand for NAD+ by PARP-1 to repair increasing oxidative DNA damage

Delicious and Convenient: Skip the capsulesenjoy a daily serving of this L-glutathione supplement in a tasty mixed berry flavor

February 2012

Certain metabolic intermediates derived from GSH catabolism can enter the tricarboxylic acid (TCA) cycle, thereby supporting mitochondrial ATP production (7)