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doi: 10.1007/s00018-014-1762-5 209 RutherfordNJSacinoANBrooksMCeballos-DiazCLaddTBHowardJKet al

Limited human data exists, mostly anecdotal reports and case observations, and no controlled clinical trials have confirmed direct muscle growth or hypertrophy benefits

Inactivation of system Xc - or dysfunction in GSH synthesis leads to reduced GPX4 activity, impairing cellular antioxidant capacity and ultimately resulting in ferroptosis

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