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In 2017, liraglutide became the first GLP-1 receptor agonist approved by the FDA to reduce the risk of major adverse cardiovascular events in adults with type 2 diabetes and established cardiovascular disease, based on results from the LEADER trial

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Lancet 398 (10295), 143155 (2021)

For example, individuals in the cohorts were older and mostly white men, thus hurting the results generalizability to the general population, while the researchers could not rule out residual confounding

Tanguturi Yella SS, Kota Sesha Brahma Sree KS, Mahato SK (2025) The Role of Glucagon-Like Peptide-1 Receptor Agonists in the Treatment of Alcohol Use Disorder: Current Evidence and Future Directions