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43 These interactions enable lactate to regulate cytokines, chemokines, adhesion molecules, and signaling pathways (Figure 1) for the expression of several enzymes taking part in immune response and metabolism, elucidating its differential effects on inflammatory processes beyond its role as a well-known metabolic waste product

Sigma-Aldrich, 472301) at 1020 mM and added at the indicated concentrations

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NMN is well tolerated in healthy participants who received 300, 600, or 900 mg per day for a total of 60 days 322,323 , with all NMN doses increasing blood NAD + levels, and no adverse events were observed