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In a randomized trial, 74 RA patients were given either 600 mg of NAC or a placebo twice daily for three months

This method, based on the Kolmogorov-Smirnov (KS) like random walk statistic, allows to produce a bimodal distribution of enrichment scores by generating non-zero maximum deviations under the null distribution

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Furthermore, it was shown that mild perturbation of mitochondrial function, like the electron transport chain, by doxycycline can activate disease tolerance mechanisms, such as tissue repair and metabolic reprogramming in sepsis

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