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First-Dose Side Effects and What to Expect Common first-dose experiences with tirzepatide include mild nausea (reported in 25-30% of patients in clinical trials), reduced appetite within 3-5 days, and occasional loose stools as your digestive system adjusts to altered satiety signals

Eli Lillys oral strategy is focused on orforglipron, a separate GLP-1 medication

It therefore tracks that as you make positive progress towards your health goals on a weight management programme, your self-esteem and perception of self will improve (alongside potential external attention!)

See the in-depth KPV guide

For people with metabolic syndrome or multiple cardiovascular risk factors, this broader metabolic improvement is potentially more important than the weight loss itself