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In the classic 2002 NEJM study designed to prevent the transition of pre-diabetes to frank type 2 diabetes in adults [Reference Knowler, Barrett-Connor and Fowler20], the authors concluded, Lifestyle changes and treatment with metformin both reduced the incidence of diabetes in persons at high risk

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Beyond the pineal gland, several cell types, including enterochromaffin cells of the gut, retinal photoreceptors, and ovarian granulosa-cumulus cells, also generate melatonin (180182)

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The core of our review focuses on proteomics insights into the unique physiology, metabolism, and stress responses mechanisms of these microorganisms (Figure 2)