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No randomized trials No controlled studies No validated imaging or outcome measures Only one very small, biased case series 2
In an ongoing phase 1a/1b trial of leptomeningeal metastases (malignant cells in the CSF), IT DFO will be tested through an Ommaya reservoir to determine the highest dose of DFO that can be tolerated (Clinicaltrials.gov, 2025), but full results are still pending
Mechanistically, targeting CD38 improved T cell glucose metabolism and mitochondrial mass in vitro, attenuated hippocampal glucose hypometabolism, as well as cortical IL-1-driven inflammation in vivo, an AD hallmark associated with disease progression 71,72 , linking metabolism and immunity 73
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for example, "Patient to receive weekly B12 injections for four weeks, followed by monthly maintenance." Follow-Up Visits : Schedule and document follow-up assessments
