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In the model proposed by Lee, homocysteine is shunted away from the methionine synthesis pathway and toward the GSH synthesis pathway, creating a relative deficiency of methyl donors in order to keep up with increased demand for the glutathione needed for POP conjugation ( Fig 3 )

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The tumor volume (in mm) was calculated using the formula V = (a b)/2, where a represents the length and b denotes the width of the tumor

Excessive use of these medications may potentially overwhelm the bodys glutathione reserves and lead to liver damage

This suggests that CaOx crystals may induce ferroptosis through autophagy and promote kidney stone development