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The effect was stronger in those who self-identified as poor sleepers, reported usually taking a long time to fall asleep, and those who smoked

doi: 10.1038/ncomms10894 262 OfengeimD.MazzitelliS.ItoY.DeWittJ

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This provides a rationale for the effect of mutagenesis of R190 2.60 and K197 2.67 , which were two of the few TMD residues that had a large impact on exendin-P5 affinity (Supplementary Figs 5 and 9)