Epithalon is popular in longevity research because it is often discussed in connection with cellular aging, telomere-related studies, and biological regulation
It upregulates genes involved in collagen synthesis (COL1A1, COL3A1, COL5A1), extracellular matrix remodeling (decorin, fibromodulin), and antioxidant defense (superoxide dismutase, glutathione peroxidase) while simultaneously suppressing genes associated with inflammation (IL-6, TNF-alpha), fibrinogen production, and tissue destruction (several MMPs)
For example, growth hormone-releasing peptides increase levels of IGF-1, a hormone involved in tissue growth and repair
Notably, levels returned to baseline after a 1-month washout period, indicating that continuous supplementation is required to maintain elevated levels
Using liposomal delivery protects glutathione from being destroyed in the stomach, which may reduce the likelihood of skin irritations and digestive issues caused by unabsorbed supplements