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Of the intranasally challenged mice, 20% developed meningitis without bacteremia, and the authors found that the infection induced a decreased expression and a relocation of the junction protein N-cadherin in the olfactory epithelium, which connects the nasopharynx with the CNS

7 For now, more than 100 T2D-susceptibility genes have been mapped in human including TCF7L2, GCK, KCNJ11, PPARG

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These findings suggest that NHPN-1010 could be a beneficial agent for the treatment of NIT through reversal of cochlear synapthopathy in the IHC area and suppression of neuronal hyperactivity in the CAS

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