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In 2021, it was found that tripartite motif-containing protein 46 (TRIM46) contributes to high-glucose-induced ferroptosis of human retinal capillary endothelial cells by promoting the ubiquitination of GPX4, that SLC7A11 can reduce laser-induced choroidal neovascularization by inhibiting RPE ferroptosis, and that heme oxygenase-1 (HO-1)-mediated ferroptosis can serve as a target for protecting retinal pigment epithelial degeneration

D'Alessandro MCB, Kanaan S, Geller M, Pratico D, Daher JPL

In a randomized, double-blind, placebo-controlled trial, tesamorelin reduced liver fat and was associated with less fibrosis progression, and a targeted proteomic and transcriptomic analysis of that trial showed the drug lowered fibro-inflammatory mediators including VEGFA, TGF-1, and CSF1

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Safety and efficacy of insulin degludec/liraglutide (IDegLira) added to sulphonylurea alone or to sulphonylurea and metformin in insulin-nave people with type 2 diabetes: the DUAL IV trial