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However, some patients report experiencing them during treatment, possibly due to indirect mechanisms such as weight loss and hormonal changes

Tissue distribution [edit] The POMC gene is expressed in both the anterior and intermediate lobes of the pituitary gland

This recognition is mediated by specialized molecular sensors, including pattern recognition receptors (PRRs), activated by damage-associated molecular pattern (DAMP) molecules produced upon exogenous threats and endogenous danger signals, subsequently activating inflammatory cascades [141, 142]