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From rainbow diet pills packed with amphetamines and diuretics that were marketed to women beginning in the 1940s, to the 1990s rise and fall of fen-phen, which triggered catastrophic heart and lung conditions, history is beset by failures to find safe, successful weight loss drugs. Now, Couzin-Frankel added, GLP-1 drugs appear to be breaking the moldand there are signs that they could also provide significant benefits for patients with a wide range of other conditions, including heart disease and chronic kidney disease