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This narrative review tries to understand the research currently accessible on the function of different biological entities in the treatment of PDN
A practical approach: halve the sulfonylurea dose at GLP-1 RA initiation and retitrate upward only if postprandial glucose remains above target for two consecutive weeks
It does not build muscle, fix sleep, or repair a difficult relationship with food, so patients who treat it as a partner to their own effort get the best outcomes
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In particular, vitamin E, after acting as an antioxidant by reducing lipid radicals, is restored to its reduced form by vitamin C
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