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Activation of the GLP-1 receptor enhances insulin secretion in response to meals, slows gastric emptying, and suppresses appetite through signaling in the central nervous system

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Some studies have reported that depression caused by chronic stress disrupts the BDNFtropomyosin related kinase B (TrkB) receptor signaling pathway in the PFC and hippocampus, and ultimately contributes to impaired synaptic maturation, synaptic protein synthesis, and glutamate receptor cycling (Collingridge et al., 2010