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[37] that high glucose induces PSC activation by OxS

At the same time, neuroprotective agents that help protect the nervous system from damage, have positive effects on improving mitochondrial function and scavenging free radicals, as well as inhibiting the inflammatory process and thus reducing neuronal death [7]

Deregulation of these pathways is frequently observed in melasma, post-inflammatory hyperpigmentation, and senile (actinic)lentigo [154, 155, 181,182,183]

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