Cortical spreading depression (CSD), characterized by a strong wave of neuronal depolarization accompanied by glial and vascular activation, is widely believed to underlie the aura phase of migraines (24)
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This precise enzymatic action releases the fully intact, active, reduced glutathione directly into the cytoplasm, exactly where the mitochondria and cellular machinery need it to neutralize oxidative stress
469 The mitochondrial protein sideroflexin 1 (SFXN1) is responsible for importing iron from the cytoplasm to the mitochondria, and SFXN1 deficiency leads to mitochondrial respiratory chain damage, affecting the biogenesis and assembly of complex III
To a lesser extent, some studies involve aging primates or other organisms
